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InFarmatik's
strength is to find rapid quasi-optimal parameters of a chemical reaction.
The thermal kinetic studies InFarmatik conducts in small scale of solution
phase synthesis is realized by using Thermal Gradient Technology (TGT).
The basic principle of TGT is that the scope of the temperature range
is studied in a Thermal Gradient Block. In the Thermal Gradient Block,
a thermal gradient is formed by heating and cooling the two opposite walls
of the matrix reactor block. This way, during gradient operation,
the Gradient Block provides thermal zones for a number of parallel reactions,
while conventional isothermal operation only allows for
the study of reactions at the same temperature level along the block.
The reaction kinetic studies are often key factors of a successful and
economic synthesis procedure, which could be easily recorded in a Gradient
Block in gradient operation.
The core element of technology TGT is the Thermal Gradient Reactor TGR: a small scale parallel discovery unit. The first version of TGR is a 96-well format block reactor, with 0.4-ml vessel size, equipped with magnetic stirring. TRG’s first version was patented in 1999. Using gradient technology the machine can perform either gradient or isothermal operation. InFarmatik is using its proprietary technology for:
In 1999 InFarmatik received funds for further development of the Thermal
Gradient Reactor. Using this grant a new version TGR was developed with
the help of FABI ltd (Hungarian Instrumental Development Company) in
which every thermal operation is made via Peltier-element control. |