InFarmatik

5-acyl-pyrroles

Clusternumber: 34
Number of compounds: 7

Versatile templates for general drug discovery

Alfa-aminoacids

Clusternumber: 53
Number of compounds: 1

Alfa-oxo acids and esters

Clusternumber: 39
Number of compounds: 4

Temaplates suitable for syntesis of heterocyclic structures with CNS importance like piperazinones, pyrazinones and related heterocyclics.

Alfa-oxo acids and esters

Clusternumber: 67
Number of compounds: 7

Amino-acridones

Clusternumber: 30
Number of compounds: 7

Rare heterocyclic scaffolds with two anchor centers.

Aminoalcohols

Clusternumber: 48
Number of compounds: 3

3-amino-4-aryl-pyrazoles

Clusternumber: 31
Number of compounds: 7

Scaffolds with N-C-N-N kinase inhibitory motifs, suitable for synthesis of pyrimidinopyrazoles and related compouds.

3-amino-5-aryl-pyrazoles

Clusternumber: 38
Number of compounds: 4

3-amino-5-aryl-pyrazoles are scaffolds, designed for building molecules mapping kinase inhibitory space

5-amino-1-aryl-pyrazole 4-carboxylic acids and derivatives

Clusternumber: 58
Number of compounds: 8

Amino benzoic acids

Cluster number: 1
Number of compounds: 15

Amino benzoic acids and diamino-benzoic acids (in 1, 2, 3) positions are rarely available building blocks. They also serve as precursors of benzimidazoles and other important benzo-diaza-type heterocyclic ring systems.

Amino-mercapto-triazol derivates

Cluster number: 71
Number of compounds: 9

Amino nitriles

Clusternumber: 3
Number of compounds: 23

Amino nitriles are versatile precursors in the synthesis of anilino-acetic acids and other related compounds. They could also be converted to oxazoles via amide oximes.

Aminophenylpyrazole carboxylic acids

Clusternumber: 35
Number of compounds: 2

Phenyl-pyrazole carboxylic acids are important monomers in synthesis of materials of minor groove mapping compounds. Amino substituents on the phenyl end enhances the variety in thei utilization.

2-Aryl-azepanes

Clusternumber: 27
Number of compounds: 14

The cluster contains nor-nicotin analogs with 7 member ring size instead of pyrollidine. This substitutions result in an altered pharmacological profile of nicotine.

6-(hetero)aryl-2-chloronicotinic acid and derivatives

Clusternumber: 50
Number of compounds: 9

6-(hetero)aryl-2-homopiperazino-nicotinic acids and derivatives

Clusternumber: 56
Number of compounds: 9

6-(hetero)aryl-2-piperazino-nicotinic acids and derivatives

Clusternumber: 55
Number of compounds: 8

2-Aryl-indolylbutylamines

Clusternumber: 28
Number of compounds: 3

The tryptamine homologues belonging to this group are very similar in CNS activity to their natural relatives. A higher stability allows us to supply some of them in base form.

Aryl-imidazolinones

Clusternumber: 21
Number of compounds: 3

In the late 90s the synthesis and screening of disubstituted imidazolinones were described in patents for several pharma and agro applications. These mono-substituted derivatives could serve as good starting materials for library synthesis.

Aryl-malonoaldehydes

Clusternumber: 32
Number of compounds: 1

Versatile building block family for synthesis of pyrazole, pyrimidine and other heterocyclic derivatives

1-Aryl-5-Methyl-pyrazolones

Clusternumber: 70
Number of compounds: 2

5-Aryl-oxazoles

Clusternumber: 59
Number of compounds: 7

1-Aryl piperazines

Clusternumber: 47
Number of compounds: 8

Based of new ring synthesis InFarmatik released a new type of series of 1-substituted piperazines including exciting building blocks of CNS pharmacophores such as dichlorophenyls, and benzamides.

2-(hetero)aryl-quinoline-4-carboxylic acids

Clusternumber: 40
Number of compounds: 5

These compounds are building blocks for libraries with antiviral activities. Also, from this family of compounds libraries toward CNS targets (e.g. NK-2 and NK-3 antagonists) can be constructed.

Azacycloalkyl-azacycloalkanes

Clusternumber: 43
Number of compounds: 4

Prryolidines and azepanes containing alyclic and heterocyclic rings are convenient and promising building blocks for medicinal chemistry focusing on CNS targets.

Benzodiazepines

Clusternumber: 4
Number of compounds: 31

Benzodiazepines have been widely used for CNS targets. Recently, the antineoplasm effect of tetrahydro-benzodiazepines were exploited. This cluster contains ring systems with various oxidation forms and with unique substituents.

Bicyclic mapping spacers

Clusternumber: 62
Number of compounds: 7

Boc protected scaffolds

Clusternumber: 5
Number of compounds: 150

InFarmatik published the selective mono-Boc protection of diamines in a series of posters. Most members of InFarmatik's non-natural amino acid selection are also available or can be ordered beside the mono protected diamines and diaza-heterocyclics.

Camphoroxime ethers

Clusternumber: 61
Number of compounds: 5

2-chloro-quinoline-3-carbaldehydes

Clusternumber: 51
Number of compounds: 2

Diamines

Clusternumber: 6
Number of compounds: 11

Diamines are widely used in the chemical and pharmaceutical industry. They can be used as spacers in drug design, in other chemical applications and polymer chemistry.

1,3-diazaspiro[4,5]-decenones

Clusternumber: 54
Number of compounds: 2

Dioxocarboxylic acids and esters

Clusternumber: 7
Number of compounds: 19

Dioxocarboxylic acids and esters are pharmacologically active, also they are important intermediates in the syntheses of pyrazoles and benzodiazepine type compounds. In addition, InFarmatik offers various heterocyclic scaffolds and building blocks started from this family of compounds.

Ethylamines

Clusternumber: 23
Number of compounds: 18

1-Ethylamines of (hetero)aromatic systems are compounds with great pharmaceutical importance. Beside their due pharmacological effects (CNS) they also serve as good model structures for resolution trials having an unsymmetrical carbon with distinguished substituents next to primary amine.

Etyhl-N-hydroxylamines

Clusternumber: 26
Number of compounds: 9

Ethyl-N-hydroxylamines are close analogs of ethylamines less readily available. Most of them can be prepared on low scale at a very low yield, so they are available in small quantity only. Most of them can be prepared in small scale at a very low yield, they are available in small quantities only.

Ethynyl benzaldehydes

Clusternumber: 8
Number of compounds: 6

Ethynyl benzaldehydes are reactive scaffolds, but also sensitive in many reaction conditions. The acetylene groups can be further reacted in Sonogashira reactions.Working with these scaffolds requires special experience, therefore InFarmatik offers its services for custom directed syntheses.

Fused imidazoles

Clusternumber: 9
Number of compounds: 141

A wide variety of imidazoles (benzimidazoles, imidazopyridines, imidazopyrimidines and imidazopyrazines) with different functional groups are available to explore many pharmaceutical-, agro- and vetenary applications.

Homopiperazines

Clusternumber: 24
Number of compounds: 5

Currently some of these compounds are not supplied. The listed compounds are various 2-, and N-aryl homopiperazin derivatives. They are referred to as "the pharmacophore amine part" of CNS-active compounds.

Imidazopyridazines

Clusternumber: 63
Number of compounds: 21

Indoles

Clusternumber: 10
Number of compounds: 10

This collection consists of 2-heteroaryl-indol and stable 2-heteroaryl-3-carboxaldehyde-indole derivatives.

Indolizines

Clusternumber: 36
Number of compounds: 20

These are Rare chemical structures including carboxylic acid, chloro and carboxaldehyde derivatives

Kinase blocks with aliphatic linker

Clusternumber: 41
Number of compounds: 3

A subset of the aminopyrazoles designed at InFarmatik was converted to pyrazolopyrimidines in a special way that resulted in the addition of a hydroxypropyl linker. This linker renders these building blocks suitable for the construction of various libraries that can explore alternative binding sites in different kinase targets

Monotosyl-dinucleophiles

Clusternumber: 46
Number of compounds: 2

Versatile building blocks for synthesis of ortho disubstituted compounds or heterocyclics

Naphtyridine esters

Clusternumber: 68
Number of compounds: 1

Nicotinic acids

Clusternumber: 2
Number of compounds: 22

This list consists of nicotinic acid derivatives substituted in positions 2 and 6. Using InFarmatik's proprietary methods, 2- and 6-halo-nicotinic acid derivatives were synthesized, and were coupled to a variety of amines (proprietary amine building blocks, piperazines, etc.) to obtain the products.

N-phenyl-aminopyrazoles and derivatives

Clusternumber: 52
Number of compounds: 7

Phamacology standards

Clusternumber: 74
Number of compounds: 8

Phenazines

Clusternumber: 37
Number of compounds: 5

In 1976 Rewcastle and co-workers found that many phenazine-1-carboxylic acid derivatives were effective against certain types of cancer. Since, this family of compound has been widely used as scaffolds for the preparation of compounds to be tested in oncology.

Piperazines

Clusternumber: 12
Number of compounds: 30

Substituted piperazines are potential drug candidates in CNS indication. Also, they provide a skeleton of interesting fused heterocyclic products.

Protected spiro aminoamidoximes

Clusternumber: 60
Number of compounds: 2

Pyrazine derivatives

Clusternumber: 13
Number of compounds: 42

Pyrazin core is frequently used in focused libraries. A key issue in the library synthesis is the stability of the templates. The present list consists of stable pyrazine derivatives.

Pyrazole-4-carbaldehydes

Clusternumber: 64
Number of compounds: 2

Pyrazole carboxylic acids

Clusternumber: 14
Number of compounds: 37

Pyrazoles are important structural motifs in many pharmaceutical products. Lately they are gaining significance in anticancer and anti-HIV research.

1-H-pyrazolo[3,4-b]pyridin-3-ylamines

Clusternumber: 57
Number of compounds: 2

Pyrazolopyrimidines

Clusternumber: 33
Number of compounds: 12

InFarmatik synthesized a series of compounds with potential kinase inhibitory activity. Some of the structures were described in the literature as effective inhibitors. The list also contains a new aminopyrazole core

Pyridines

Clusternumber: 15
Number of compounds: 28

This list contains pyridines substituted in positions 2, 3, and 4. These compounds are stable precursors of more complex novel, non-existing compounds, as well for compounds that decompose during storage (e.g. isolated isonitriles of amino ethyl pyridines are not stable, while their formamide precursors are stable).

Pyridopyrimidines

Clusternumber: 69
Number of compounds: 3

Pyrimidinopyrazole aldehydes

Clusternumber: 65
Number of compounds: 4

Pyrollines and pyrollidines

Clusternumber: 16
Number of compounds: 34

The preparation of a wide range of 2-aryl pyrollines and pyrrollidines was accomplished based on InFarmatik’s experience in "nicotine chemistry". We are capable to manufacture all the pyridine isomers and many other heterocyclic compounds in large scale.

Quinoxalines

Clusternumber: 17
Number of compounds: 23

There is a strong demand for the rare Quinoxaline carboxylic acids and amines for library synthesis. This sublibrary includes both disubstituted derivatives, and uniquely mono-substituted 2- and 3-heteroaryl and aryl derivatives.

Retrohydroxamates

Clusternumber: 75
Number of compounds: 2

Saturated fused heterocycles

Clusternumber: 18
Number of compounds: 18

InFarmatik offers a collection of heterocyclic benzodiaza derivatives. The compounds have various sizes of fused diaza rings. The list also includes isomers of the tetrahydro-benzodiazepine ring.

Spirooxiranes

Clusternumber: 73
Number of compounds: 3

Substituted-imidazoles

Clusternumber: 22
Number of compounds: 6

An exemplary structure for MCR-product started from available simple chemicals (thiphene-3-carboxaldehyde and 2-amino-etansulphonic acid) and GL-067 TOSMIC.

Substituted-imidazoles

Clusternumber: 66
Number of compounds: 21

Terpenoid analogs

Clusternumber: 72
Number of compounds: 5

Thiadiazoles

Clusternumber: 42
Number of compounds: 3

Convenient starting materials for building compound libraries for CNS indications.

Thiazol-2-ols

Clusternumber: 29
Number of compounds: 3

The thiazol compounds find in this library contain the active motive of building blocks of CRF targeted libraries.

Thioureas

Clusternumber: 44
Number of compounds: 6

Thioureas linked to alycyclic, pyridine and pyrazine derivatives are used as building blocks for various heterocyclic ring systems, such as pyrimidines, pyrazolin-thiones etc..

TOSMIX

Clusternumber: 19
Number of compounds: 16

A very basic tool in MCRs is isocyanide. Tosylmetyl-isocyanides are thermally stable building blocks for fabricating mono-, di- and trisubstituted hetereocycles, mainly imidazoles.

Triazatricyclobispiranone scaffolds

Clusternumber: 49
Number of compounds: 5

Tryptamines

Clusternumber: 20
Number of compounds: 16

Similarly to indoles, the 2-pyridyl substitutions are frequently used tryptamine derivatives. Some 7- and many 5-substituted halogen derivatives make the collection complete.

Miscellaneous

Clusternumber: 11
Number of compounds: 167

From the displayed beautiful butterfly structure through mono alkylated polyamines, phenazines and oxindoles this list contains a wide variety of diverse building blocks and scaffolds.

Kiloproducts

Clusternumber: 45
Number of compounds: 14

This lists contains structures with familiar motifs of block buster compounds, as well as interesting and valuable building blocks that are usually not available in pure form and larger quantity. Materials in this cluster can be produced at larger scale.